1) first of all - прежде всего
First of all, Dr Zoidberg, do you even have a medical degree?
2) deep down - в глубине души (на самом деле)
I have misgivings about this mission, but deep down, I know we're doing the right thing
3) by the way - кстати
And by the way, Sherman didn't even get laid.
4) in short / in brief / in a word - короче
In short: I think it's time to start talking about a divorce.
5) as to / as for - что касается
As for why they didn't film in Scotland, no idea, probably a budget issue.
6) for one's part / on one's part - что касается конкретного человека
I know for my part that I'd surrender everything, honor included, in order to get out of the mess.
7) believe it or not - веришь или нет, но
Believe it or not, I have more important things to do today than laugh and clap my hands.
8) look here - послушай
Look here, Fillmore, what is it you'd really like to do? Tell me!
9) above all - прежде всего
But above all it made me think about things.
10) in all probability / in all likelihood - по всей вероятности
February 13th, 2001, was in all probability a day neither more nor less amazing than any other day
11) needless to say - нет нужды говорить
My father and I don't get along; he doesn't approve of my lifestyle and, needless to say, I don't approve of his.
12) something tells me - что-то мне подсказывает,.
Something tells me I could easily beat those trained professionals.
13) after all - в конце концов
I didn't think you'd show your face around me again. I figured you were humiliated. You did run away, after all.
14) what's more - кроме того
I would say: "Sure! Sure, I'm in love with her! And what's more, I'm going to be faithful to her!"
15) the thing is - дело в том,
Well, the thing is, I don't want to stay at any hotels on the East Side where I might run into some acquaintances of mine.